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Daved H. Fremont, PhD

Daved H. Fremont, PhD

Principal Investigator

Professor, Department of Pathology and Immunology

Professor, Department of Biochemistry and Molecular Biophysics

Education

  • BS, Chemical Engineering: University of Wisconsin, Madison, WI (1986)
  • PhD, Biochemistry: University of California, La Jolla, CA (1993)
  • PostDoc, Molecular Biophysics: Columbia University, New York City, NY (1994-98)
  • PostDoc, Immunology: National Jewish Center, Denver CO (1994-98)

Education/Training Program Affiliations

Research Summary

Investigating mechanisms of host immunity and viral evasion.

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Christopher A. Nelson, PhD

Assistant Professor, Pathology & Immunology

Education

  • BS, Chemical Engineering: University of Wisconsin-Madison, Madison, WI (1985)
  • PhD, Immunology & Molecular Biology: Washington University, St. Louis, MO (1994)
  • PostDoc, Pathology & Immunology: Washington University, St. Louis, MO (1994-1998)

Awards

  • Spencer T. Olin Award (1994)

Research

Several poxvirus immune evasion proteins make use of a conserved β-sandwich-domain that we propose calling a “PIE scaffold”. PIE domain-containing proteins are abundant among chordopox. We estimate there may be as many as 20 separate PIE families. My current aim is to determine the function of as many PIEs as possible, to understand their role in immune evasion, and by x-ray crystallography understand how they bind so many disparate ligands.

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Yanan Dai, PhD

Staff Scientist

Education

  • BS, Pharmacy: Tianjin University, Tianjin, China (2008)
  • PhD: University of Science and Technology of China, Hefei, China (2013)

Research interests

  • Structural basis of antibody-mediated protection of influenza virus
  • Structural analysis of natural killer cell receptors and ligands
Sangeeta Yadav

Sangeeta Yadav

Postdoctoral Research Associate

Education

  • B.Sc. in Botany, University of Delhi, India (2015)
  • M.Sc. in Biotechnology, Vellore Institute of Technology (VIT), Vellore, India (2017)
  • Ph.D. in Nanobiotechnology, VIT, Vellore, India (2022)

Awards

  • Recipient of research grant from DBT-Government of India and US-Foldscope
  • Awarded International Travel Grant by the Department of Science and Technology-SERB, India

Research Interests
My research focuses on understanding the molecular mechanisms underlying Alphavirus-host interactions, with an emphasis on identifying potential strategies to inhibit viral entry and replication. I am particularly interested in characterizing virus-receptor interactions using biophysical and biochemical approaches, and in studying antibody-virus binding at the atomic level to inform therapeutic and vaccine development.

Paige D. Hall

Paige D. Hall

Postdoctoral Research Associate

Education

  • BS, Biochemistry: Texas Woman’s University, Denton, TX (2017)
  • PhD, Biochemistry, Biophysics, and Structural Biology: Washington University in St. Louis, St. Louis, MO (2025)

Awards

  • Chancellor’s Student Research Scholar (2017)
  • ACS-Dallas/Ft. Worth Outstanding Undergraduate Student (2017)
  • American Society for Virology Student Travel award (2020 and 2022)
  • Future of Science Fund scholarship, Keystone Symposium (2024)

Research

I research the strategies and mechanisms used by poxviruses, coronaviruses, and astroviruses to engage with and evade the host immune system. To achieve this, I employ biophysical and biochemical techniques to understand these protein-protein interactions on a macromolecular level, and structural biology to determine atomic structure.

Sean Hui

Sean Hui

PhD Candidate: Molecular Microbiology and Microbial Pathogenesis

Education

  • BS, General Biology: University of California – San Diego, La Jolla, CA (2015)

Research

Structural perspectives of host-pathogen interactions in arboviruses.

 

Michael N. Nguyen

Michael N. Nguyen

PhD Candidate: Molecular Microbiology and Microbial Pathogenesis

Education

  • BS, Microbiology, University of California – San Diego, La Jolla, CA (2019)

Other Institutions

  • La Jolla Institute for Immunology (2020-2023)

Research

My current work focuses on characterizing the prefusion intermediate conformation states using antibody and potential host-cell receptors, with a current focus on flavivirus.

Shiqi "Ally" Cao

Shiqi “Ally” Cao

PhD Candiate: Immunology

Education

  • BS, Biological Sciences: University of Chicago, Chicago, IL (2024)

Lab Alumni

Haiyan Zhao

Postdoctoral research associate 

Currently a Professor at Wuhan University

Xiaoli Wang

Assistant Professor, Pathology and Immunology

Currently retired

Arthur S. Kim

PhD student in Molecular Microbiology and Microbial Pathogenesis program (completed 2020)

Ian B. Harvey

PhD student in Biochemistry, Biophysics, and Structural Biology program (completed 2020)

Currently a postdoctoral fellow at New York University

Jabari I. Elliott

PhD student in Biochemistry, Biophysics, and Structural Biology program (completed 2020)

Currently a senior consultant for EY-Parthenon

Lily Xu

Undergraduate student (received BS in 2020)

Currently a PhD student in the Microbiology and Immunology at Stanford University

Katherine Basore

PhD student in Biochemistry, Biophysics, and Structural Biology (completed 2021)

Currently a Staff Scientist at the Washington University Center for Cellular Imaging (WUCCI)

John M. Errico

PhD student in Immunology (Completed 2022)

Currently a Scientist at Vir Biotechnology

Maxwell Zimmerman

Postdoctoral researcher

Currently a Scientist at Generate Biomedicines

Brittany K. Smith

PhD student in Molecular Biophysics

Currently a Bioinformatics Scientist at Washington University

Lucas J. Adams

MSTP student in Immunology (completed 2024)

Currently completing medical school at Washington University School of Medicine