Publications

Selected Journal Articles

Below are a select group of publications.

All articles from the Fremont Lab can be found here.

  1. Raju S, Palakurty S, Sariol A, Wagoner N, Adams LJ, Hui S, Klimstra WB, Fremont DH, Diamond MS. Structural basis for plasticity in receptor engagement by an encephalitic alphavirus. Cell. 2025 Apr 4:S0092-8674(25)00272-7. doi: 10.1016/j.cell.2025.02.036.
  2. Ingle H, Molleston JM, Hall PD, Bui D, Wang L, Bhatt KD, Foster L, Antia A, Ding S, Lee S, Fremont DH, Baldridge MT. The neonatal Fc receptor is a cellular receptor for human astrovirus. Nat Microbiol. 2024 Dec;9(12):3321-3331. doi: 10.1038/s41564-024-01855-y.
  3. Case JB, Sanapala S, Dillen C, Rhodes V, Zmasek C, Chicz TM, Switzer CE, Scheaffer SM, Georgiev G, Jacob-Dolan C, Hauser BM, Dos Anjos DCC, Adams LJ, Soudani N, Liang CY, Ying B, McNamara RP, Scheuermann RH, Boon ACM, Fremont DH, Whelan SPJ, Schmidt AG, Sette A, Grifoni A, Frieman MB, Diamond MS. A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice. Cell Host Microbe. 2024 Dec 11;32(12):2131-2147.e8. doi: 10.1016/j.chom.2024.10.016. 
  4. Tong K, Hernandez EM, Basore K, Fremont DH, Lai JR. Chikungunya virus E2 B domain nanoparticle immunogen elicits homotypic neutralizing antibody in mice. Vaccine. 2024 Dec 2;42(26):126405. doi: 10.1016/j.vaccine.2024.126405.
  5. Palakurty S, Raju S, Sariol A, Chong Z, Wagoner N, Ma H, Zimmerman O, Adams LJ, Carmona C, Liu Z, Fremont DH, Whelan SPJ, Klimstra WB, Diamond MS. The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses. Cell Rep. 2024 Oct 22;43(10):114809. doi: 10.1016/j.celrep.2024.114809.
  6. Adams LJ, Raju S, Ma H, Gilliland T Jr, Reed DS, Klimstra WB, Fremont DH, Diamond MS. Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. Cell. 2024 Jan 18;187(2):360-374.e19. doi: 10.1016/j.cell.2023.11.031. 
  7. Ma H, Adams LJ, Raju S, Sariol A, Kafai NM, Janova H, Klimstra WB, Fremont DH, Diamond MS. The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses. Nat Commun. 2024 Jan 4;15(1):246. doi: 10.1038/s41467-023-44624-x. 
  8. Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Chong Z, Whitener BM, Shrihari S, Jethva PN, Gross ML, Crowe JE Jr, Whelan SPJ, Diamond MS, Fremont DH. A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection. Cell Rep Med. 2023 Dec 19;4(12):101305. doi: 10.1016/j.xcrm.2023.101305. 
  9. Zimmerman O, Zimmerman MI, Raju S, Nelson CA, Errico JM, Madden EA, Holmes AC, Hassan AO, VanBlargan LA, Kim AS, Adams LJ, Basore K, Whitener BM, Palakurty S, Davis-Adams HG, Sun C, Gilliland T Jr, Earnest JT, Ma H, Ebel GD, Zmasek C, Scheuermann RH, Klimstra WB, Fremont DH, Diamond MS. Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8. Cell. 2023 Oct 26;186(22):4818-4833.e25. doi: 10.1016/j.cell.2023.09.007. 
  10. Iyer RF, Edwards DM, Kolb P, Raué HP, Nelson CA, Epperson ML, Slifka MK, Nolz JC, Hengel H, Fremont DH, Früh K. The secreted protein Cowpox Virus 14 contributes to viral virulence and immune evasion by engaging Fc-gamma-receptors. PLoS Pathog. 2022 Sep 19;18(9):e1010783. doi: 10.1371/journal.ppat.1010783. 
  11. Errico JM, Adams LJ, Fremont DH. Antibody-mediated immunity to SARS-CoV-2 spike. Adv Immunol. 2022;154:1-69. doi: 10.1016/bs.ai.2022.07.001.
  12. Errico JM, Zhao H, Chen RE, Liu Z, Case JB, Ma M, Schmitz AJ, Rau MJ, Fitzpatrick JAJ, Shi PY, Diamond MS, Whelan SPJ, Ellebedy AH, Fremont DH. Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD. Cell Rep. 2021 Oct 26;37(4):109881. doi: 10.1016/j.celrep.2021.109881. 
  13. Basore K, Ma H, Kafai NM, Mackin S, Kim AS, Nelson CA, Diamond MS, Fremont DH. Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor. Nature. 2021 Oct;598(7882):672-676. doi: 10.1038/s41586-021-03963-9. 
  14. Chen RE, Smith BK, Errico JM, Gordon DN, Winkler ES, VanBlargan LA, Desai C, Handley SA, Dowd KA, Amaro-Carambot E, Cardosa MJ, Sariol CA, Kallas EG, Sékaly RP, Vasilakis N, Fremont DH, Whitehead SS, Pierson TC, Diamond MS. Implications of a highly divergent dengue virus strain for cross-neutralization, protection, and vaccine immunity. Cell Host Microbe. 2021 Nov 10;29(11):1634-1648.e5. doi: 10.1016/j.chom.2021.09.006. 
  15. VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe JE Jr, Whelan SPJ, Fremont DH, Diamond MS. A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope. Immunity. 2021 Oct 12;54(10):2399-2416.e6. doi: 10.1016/j.immuni.2021.08.016. 
  16. Smith BK, Janowski AB, Danis JE, Harvey IB, Zhao H, Dai YN, Farnsworth CW, Gronowski AM, Roper S, Fremont DH, Wang D. Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA. mSphere. 2021 Feb 3;6(1):e01207-20. doi: 10.1128/mSphere.01207-20.
  17. Madsen A, Dai YN, McMahon M, Schmitz AJ, Turner JS, Tan J, Lei T, Alsoussi WB, Strohmeier S, Amor M, Mohammed BM, Mudd PA, Simon V, Cox RJ, Fremont DH, Krammer F, Ellebedy AH. “Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective.” Immunity. 2020 Oct 13;53(4):852-863.e7. doi: 10.1016/j.immuni.2020.08.015.
  18. Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, Chen RE, Winkler ES, Wessel AW, Case JB, Kashentseva E, McCune BT, Bailey AL, Zhao H, VanBlargan LA, Dai YN, Ma M, Adams LJ, Shrihari S, Danis JE, Gralinski LE, Hou YJ, Schäfer A, Kim AS, Keeler SP, Weiskopf D, Baric RS, Holtzman MJ, Fremont DH, Curiel DT, Diamond MS. “A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.” Cell. 2020 Oct 1;183(1):169-184.e13. doi: 10.1016/j.cell.2020.08.026.
  19. Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Smith BK, Shrihari S, McCune BT, Harvey IB, Keeler SP, Bloyet LM, Zhao H, Ma M, Adams LJ, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ, Diamond MS. “Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.” Cell Host Microbe. 2020 Jul 30:S1931-3128(20)30421-2. doi: 10.1016/j.chom.2020.07.018. Online ahead of print.
  20. Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. “Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.” Cell Host Microbe. 2020 Jul 3:S1931-3128(20)30362-0. doi: 10.1016/j.chom.2020.06.021. Online ahead of print.
  21. Kim AS, Zimmerman O, Fox JM, Nelson CA, Basore K, Zhang R, Durnell L, Desai C, Bullock C, Deem SL, Oppenheimer J, Shapiro B, Wang T, Cherry S, Coyne CB, Handley SA, Landis MJ, Fremont DH, Diamond MS. “An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.” Cell Host Microbe. 2020 Mar 11;27(3):428-440.e9. doi: 10.1016/j.chom.2020.01.008. Epub 2020 Feb 18.
  22. Zhao H, Xu L, Bombardi R, Nargi R, Deng Z, Errico JM, Nelson CA, Dowd KA, Pierson TC, Crowe JE, Diamond MS, Fremont DH. “Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge.” J Exp Med. 2020 Feb 3;217(2):e20191792. doi: 10.1084/jem.20191792.
  23. Wang X, Piersma SJ, Elliott JI, Errico JM, Gainey MD, Yang L, Nelson CA, Yokoyama WM, Fremont DH. “Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation.” Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21113-21119. doi: 10.1073/pnas.1909414116. Epub 2019 Oct 1.
  24. Hassan AO, Dmitriev IP, Kashentseva EA, Zhao H, Brough DE, Fremont DH, Curiel DT, Diamond MS. “A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy.” Cell Rep. 2019 Sep 3;28(10):2634-2646.e4. doi: 10.1016/j.celrep.2019.08.005.
  25. Sherman MB, Williams AN, Smith HQ, Nelson C, Wilen CB, Fremont DH, Virgin HW, Smith TJ. “Bile salts alter the mouse norovirus capsid conformation; possible implications for cell attachment and immune evasion.” J Virol. 2019 Jul 24. pii: JVI.00970-19. doi: 10.1128/JVI.00970-19.
  26. Earnest JT, Basore K, Roy V, Bailey AL, Wang D, Alter G, Fremont DH, Diamond MS. “Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity.” J Exp Med. 2019 Jul 23. pii: jem.20190736. doi: 10.1084/jem.20190736.
  27. Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH. “Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.” Cell. 2019 May 6. pii: S0092-8674(19)30392-7. doi: 10.1016/j.cell.2019.04.006.
  28. Harvey IB, Wang X, Fremont DH. “Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation.” PLoS Pathog. 2019 Apr 29;15(4):e1007711. doi: 10.1371/journal.ppat.1007711.
  29. Fox JM, Roy V, Gunn BM, Huang L, Edeling MA, Mack M, Fremont DH, Doranz BJ, Johnson S, Alter G, Diamond MS. “Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes.” Sci Immunol. 2019 Feb 22;4(32). pii: eaav5062. doi: 10.1126/sciimmunol.aav5062.
  30. Salazar V, Jagger BW, Mongkolsapaya J, Burgomaster KE, Dejnirattisai W, Winkler ES, Fernandez E, Nelson CA, Fremont DH, Pierson TC, Crowe JE Jr, Screaton GR, Diamond MS. “Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.” Cell Rep. 2019 Feb 5;26(6):1585-1597.e4. doi: 10.1016/j.celrep.2019.01.052.
  31. Wang X, Piersma SJ, Nelson CA, Dai YN, Christensen T, Lazear E, Yang L, Sluijter M, van Hall T, Hansen TH, Yokoyama WM, Fremont DH. “A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement.” Elife. 2018 Dec 21;7. pii: e38667. doi: 10.7554/eLife.38667.
  32. Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE Jr, Slifka MK, Fremont DH, Klimstra WB, Diamond MS. “Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.” Nat Microbiol. 2019 Jan;4(1):187-197. doi: 10.1038/s41564-0018-0286-4. Epub 2018 Nov 19.
  33. Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH. “Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.” Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9201-E9210. doi: 10.1073/pnas. 1805797115. Epub 2018 Sep 7.
  34. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. “Mxra8 is a receptor for multiple arthritogenic alphaviruses.” Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16.
  35. Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT 4th, Gargaro M, Fremont DH, Murphy TL, Murphy KM. “Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice.” J Exp Med. 2018 May 7;215(5):1417-1435. doi: 10.1084/jem.20171784. Epub 2018 Mar 23.
  36. Fernandez E, Kose N, Edeling MA, Adhikari J, Sapparapu G, Lazarte SM, Nelson CA, Govero J, Gross ML, Fremont DH, Crowe JE Jr, Diamond MS. “Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.” MBio. 2018 Feb 27;9(1). pii: e00008-18. doi: 10.1128/mBio.00008-18.
  37. Lauron EJ, Yang L, Elliott JI, Gainey MD, Fremont DH, Yokoyama WM. “Cross-priming induces immunodomination in the presence of viral MHC class I inhibition.” PLoS Pathog. 2018 Feb 14;14(2):e1006883. doi: 10.1371/journal.ppat.1006883. eCollection 2018 Feb.
  38. Tai W, He L, Wang Y, Sun S, Zhao G, Luo C, Li P, Zhao H, Fremont DH, Li F, Jiang S, Zhou Y, Du L. “Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses.” Emerg Microbes Infect. 2018 Jan 24;7(1):7. doi: 10.1038/s41426-017-0007-8.
  39. Scott JM, Lebratti TJ, Richner JM, Jiang X, Fernandez E, Zhao H, Fremont DH, Diamond MS, Shin H. “Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice.” J Virol. 2018 Mar 14;92(7). pii: e00038-18. doi: 10.1128/JVI.00038-18. Print 2018 Apr 1.
  40. Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M. “Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.” Cell. 2018 Jan 25;172(3):534-548.e19. doi: 10.1016/j.cell.2017.11.037. Epub 2017 Dec 21.
  41. Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE. “Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.” Science. 2017 Oct 27;358(6362):518-522. doi: 10.1126/science.aan1478.
  42. Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ. “Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.” Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.
  43. Lazear E, Ghasemi R, Hein SM, Westwick J, Watkins D, Fremont DH, Krupnick AS. “Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy.” Oncoimmunology. 2017 Jan 10;6(2):e1265721. doi: 10.1080/2162402X.2016.1265721. eCollection 2017.
  44. Patel SJ, Zhao G, Penna VR, Park E, Lauron EJ, Harvey IB, Beatty WL, Plougastel-Douglas B, Poursine-Laurent J, Fremont DH, Wang D, Yokoyama WM. “A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.” J Virol. 2017 Apr 13;91(9). pii: e02463-16. doi: 10.1128/JVI.02463-16. Print 2017 May 1.
  45. Sapparapu G, Fernandez E, Kose N, Bin Cao, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, Crowe JE. “Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice.” Nature. 2016 Dec 15;540(7633):443-447. doi: 10.1038/nature20564. Epub 2016 Nov 7.
  46. Ghasemi R, Lazear E, Wang X, Arefanian S, Zheleznyak A, Carreno BM, Higashikubo R, Gelman AE, Kreisel D, Fremont DH, Krupnick AS. “Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.” Nat Commun. 2016 Sep 21;7:12878. doi: 10.1038/ncomms12878.
  47. Zuiani A, Chen K, Schwarz MC, White JP, Luca VC, Fremont DH, Wang D, Evans MJ, Diamond MS. “A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I.” J Virol. 2016 Nov 14;90(23):10499-10512. doi: 10.1128/JVI.01011-16. Print 2016 Dec 1.