Publications

Selected Journal Articles

  1. Madsen A, Dai YN, McMahon M, Schmitz AJ, Turner JS, Tan J, Lei T, Alsoussi WB, Strohmeier S, Amor M, Mohammed BM, Mudd PA, Simon V, Cox RJ, Fremont DH, Krammer F, Ellebedy AH. “Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective.” Immunity. 2020 Oct 13;53(4):852-863.e7. doi: 10.1016/j.immuni.2020.08.015.
  2. Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, Chen RE, Winkler ES, Wessel AW, Case JB, Kashentseva E, McCune BT, Bailey AL, Zhao H, VanBlargan LA, Dai YN, Ma M, Adams LJ, Shrihari S, Danis JE, Gralinski LE, Hou YJ, Schäfer A, Kim AS, Keeler SP, Weiskopf D, Baric RS, Holtzman MJ, Fremont DH, Curiel DT, Diamond MS. “A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.” Cell. 2020 Oct 1;183(1):169-184.e13. doi: 10.1016/j.cell.2020.08.026.
  3. Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Smith BK, Shrihari S, McCune BT, Harvey IB, Keeler SP, Bloyet LM, Zhao H, Ma M, Adams LJ, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ, Diamond MS. “Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.” Cell Host Microbe. 2020 Jul 30:S1931-3128(20)30421-2. doi: 10.1016/j.chom.2020.07.018. Online ahead of print.
  4. Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. “Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.” Cell Host Microbe. 2020 Jul 3:S1931-3128(20)30362-0. doi: 10.1016/j.chom.2020.06.021. Online ahead of print.
  5. Kim AS, Zimmerman O, Fox JM, Nelson CA, Basore K, Zhang R, Durnell L, Desai C, Bullock C, Deem SL, Oppenheimer J, Shapiro B, Wang T, Cherry S, Coyne CB, Handley SA, Landis MJ, Fremont DH, Diamond MS. “An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.” Cell Host Microbe. 2020 Mar 11;27(3):428-440.e9. doi: 10.1016/j.chom.2020.01.008. Epub 2020 Feb 18.
  6. Zhao H, Xu L, Bombardi R, Nargi R, Deng Z, Errico JM, Nelson CA, Dowd KA, Pierson TC, Crowe JE, Diamond MS, Fremont DH. “Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge.” J Exp Med. 2020 Feb 3;217(2):e20191792. doi: 10.1084/jem.20191792.
  7. Wang X, Piersma SJ, Elliott JI, Errico JM, Gainey MD, Yang L, Nelson CA, Yokoyama WM, Fremont DH. “Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation.” Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21113-21119. doi: 10.1073/pnas.1909414116. Epub 2019 Oct 1.
  8. Hassan AO, Dmitriev IP, Kashentseva EA, Zhao H, Brough DE, Fremont DH, Curiel DT, Diamond MS. “A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy.” Cell Rep. 2019 Sep 3;28(10):2634-2646.e4. doi: 10.1016/j.celrep.2019.08.005.
  9. Sherman MB, Williams AN, Smith HQ, Nelson C, Wilen CB, Fremont DH, Virgin HW, Smith TJ. “Bile salts alter the mouse norovirus capsid conformation; possible implications for cell attachment and immune evasion.” J Virol. 2019 Jul 24. pii: JVI.00970-19. doi: 10.1128/JVI.00970-19.
  10. Earnest JT, Basore K, Roy V, Bailey AL, Wang D, Alter G, Fremont DH, Diamond MS. “Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity.” J Exp Med. 2019 Jul 23. pii: jem.20190736. doi: 10.1084/jem.20190736.
  11. Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH. “Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.” Cell. 2019 May 6. pii: S0092-8674(19)30392-7. doi: 10.1016/j.cell.2019.04.006.
  12. Harvey IB, Wang X, Fremont DH. “Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation.” PLoS Pathog. 2019 Apr 29;15(4):e1007711. doi: 10.1371/journal.ppat.1007711.
  13. Fox JM, Roy V, Gunn BM, Huang L, Edeling MA, Mack M, Fremont DH, Doranz BJ, Johnson S, Alter G, Diamond MS. “Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes.” Sci Immunol. 2019 Feb 22;4(32). pii: eaav5062. doi: 10.1126/sciimmunol.aav5062.
  14. Salazar V, Jagger BW, Mongkolsapaya J, Burgomaster KE, Dejnirattisai W, Winkler ES, Fernandez E, Nelson CA, Fremont DH, Pierson TC, Crowe JE Jr, Screaton GR, Diamond MS. “Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.” Cell Rep. 2019 Feb 5;26(6):1585-1597.e4. doi: 10.1016/j.celrep.2019.01.052.
  15. Wang X, Piersma SJ, Nelson CA, Dai YN, Christensen T, Lazear E, Yang L, Sluijter M, van Hall T, Hansen TH, Yokoyama WM, Fremont DH. “A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement.” Elife. 2018 Dec 21;7. pii: e38667. doi: 10.7554/eLife.38667.
  16. Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE Jr, Slifka MK, Fremont DH, Klimstra WB, Diamond MS. “Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.” Nat Microbiol. 2019 Jan;4(1):187-197. doi: 10.1038/s41564-0018-0286-4. Epub 2018 Nov 19.
  17. Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH. “Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.” Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9201-E9210. doi: 10.1073/pnas. 1805797115. Epub 2018 Sep 7.
  18. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. “Mxra8 is a receptor for multiple arthritogenic alphaviruses.” Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16.
  19. Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT 4th, Gargaro M, Fremont DH, Murphy TL, Murphy KM. “Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice.” J Exp Med. 2018 May 7;215(5):1417-1435. doi: 10.1084/jem.20171784. Epub 2018 Mar 23.
  20. Fernandez E, Kose N, Edeling MA, Adhikari J, Sapparapu G, Lazarte SM, Nelson CA, Govero J, Gross ML, Fremont DH, Crowe JE Jr, Diamond MS. “Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.” MBio. 2018 Feb 27;9(1). pii: e00008-18. doi: 10.1128/mBio.00008-18.
  21. Lauron EJ, Yang L, Elliott JI, Gainey MD, Fremont DH, Yokoyama WM. “Cross-priming induces immunodomination in the presence of viral MHC class I inhibition.” PLoS Pathog. 2018 Feb 14;14(2):e1006883. doi: 10.1371/journal.ppat.1006883. eCollection 2018 Feb.
  22. Tai W, He L, Wang Y, Sun S, Zhao G, Luo C, Li P, Zhao H, Fremont DH, Li F, Jiang S, Zhou Y, Du L. “Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses.” Emerg Microbes Infect. 2018 Jan 24;7(1):7. doi: 10.1038/s41426-017-0007-8.
  23. Scott JM, Lebratti TJ, Richner JM, Jiang X, Fernandez E, Zhao H, Fremont DH, Diamond MS, Shin H. “Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice.” J Virol. 2018 Mar 14;92(7). pii: e00038-18. doi: 10.1128/JVI.00038-18. Print 2018 Apr 1.
  24. Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M. “Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.” Cell. 2018 Jan 25;172(3):534-548.e19. doi: 10.1016/j.cell.2017.11.037. Epub 2017 Dec 21.
  25. Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE. “Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.” Science. 2017 Oct 27;358(6362):518-522. doi: 10.1126/science.aan1478.
  26. Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ. “Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.” Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.
  27. Lazear E, Ghasemi R, Hein SM, Westwick J, Watkins D, Fremont DH, Krupnick AS. “Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy.” Oncoimmunology. 2017 Jan 10;6(2):e1265721. doi: 10.1080/2162402X.2016.1265721. eCollection 2017.
  28. Patel SJ, Zhao G, Penna VR, Park E, Lauron EJ, Harvey IB, Beatty WL, Plougastel-Douglas B, Poursine-Laurent J, Fremont DH, Wang D, Yokoyama WM. “A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.” J Virol. 2017 Apr 13;91(9). pii: e02463-16. doi: 10.1128/JVI.02463-16. Print 2017 May 1.
  29. Sapparapu G, Fernandez E, Kose N, Bin Cao, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, Crowe JE. “Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice.” Nature. 2016 Dec 15;540(7633):443-447. doi: 10.1038/nature20564. Epub 2016 Nov 7.
  30. Ghasemi R, Lazear E, Wang X, Arefanian S, Zheleznyak A, Carreno BM, Higashikubo R, Gelman AE, Kreisel D, Fremont DH, Krupnick AS. “Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.” Nat Commun. 2016 Sep 21;7:12878. doi: 10.1038/ncomms12878.
  31. Zuiani A, Chen K, Schwarz MC, White JP, Luca VC, Fremont DH, Wang D, Evans MJ, Diamond MS. “A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I.” J Virol. 2016 Nov 14;90(23):10499-10512. doi: 10.1128/JVI.01011-16. Print 2016 Dec 1.

All articles from the Fremont Lab can be found here.